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. 2003 Oct;2(5):1025–1035. doi: 10.1128/EC.2.5.1025-1035.2003

FIG. 4.

FIG. 4.

Cts1 is required for virulence of C. neoformans. Complement (C5)-deficient DBA mice were infected with 5 × 104 cells of the prototrophic wild-type a strain JEC20 (▪) or the congenic a cts1Δ (▴) or a cts1-570 (•) mutant (DSF42 or DSF20, respectively) (A) and the prototrophic wild-type α strain JEC21 (▪) or the congenic α cts1Δ (▴) or α cts1-570 (•) mutant (DSF45 or DSF22, respectively) (B). Mice were monitored daily for survival over 105 days, and the percentage of surviving mice was plotted versus time.