cts1Δ mutation confers a separation defect. (A) Isogenic wild-type (JEC21), cts1Δ mutant (DSF45), and cts1-570 mutant (DSF22) strains were grown to logarithmic phase at 25°C in YPD, fixed and permeabilized, stained with Alexa Fluor-conjugated WGA, and visualized by fluorescence and DIC optics. (B) Isogenic wild-type (JEC21) and cts1Δ mutant (DSF45) strains were grown to logarithmic phase at 25°C in YPD, washed, and incubated in PBS in the presence or absence of chitinase for 2 h prior to visualization by DIC optics. Magnification, ×1,000.