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. 2002 May 20;195(10):1371–1377. doi: 10.1084/jem.20020128

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — LTα is produced by a radiation-resistant cell population in the brain. (a) Survival curves of chimeric B6.Ly5.1 mice engrafted with BM from C57BL/6 (solid line), B6.TNFα^−/− (overlapping C57BL/6 mice and indicated by arrow), B6.LTα^−/− (dashed line), and B6.TNF/LTα^−/− (dotted line) mice infected with P. berghei. Results represent pooled data from three independent groups of mice (n = 4–6 per group) in experiments conducted on three separate occasions (total of n = 12–16 mice per group). Differences in survival between B6.Ly5.1 mice engrafted with BM from C57BL/6 or B6.TNFα^−/− mice and mice deficient in LTα were statistically different (χ² = 7.01, P < 0.01), as was the difference between mice engrafted with BM from B6.LTα^−/− and B6.TNF/LTα^−/− mice (χ² = 23.83, P < 0.0001). (b) LTα mRNA is detected by real-time RT-PCR in the brain of all chimeric B6.Ly5.1 mice following P. berghei infection (brain tissue collected at time of death). The source of engrafted BM is indicated. (c) Survival curve of chimeric B6.Ly5.1 mice engrafted with BM from C57BL/6, B6.TNFα^−/− or B6.LTα^−/− mice (all groups overlap; solid line), and chimeric B6.TNF/LTα^−/− mice engrafted with BM from C57BL/6 (dotted line), B6.TNFα^−/− (dashed line), or B6.LTα^−/− (dashed and dotted line) mice (n = 4 per group). Differences in survival between B6.Ly5.1 mice engrafted with BM from C57BL/6 and B6.TNF/LTα^−/− mice engrafted with BM from C57BL/6, B6.TNFα^−/−, or B6.LTα^−/− mice were statistically different (χ² = 15, P < 0.0001), as was the increased survival time of B6.TNF/LTα^−/− mice engrafted with BM from B6.TNFα^−/− mice over all other groups (χ² = 6.628, P < 0.01).

Figure 4. — LTα is produced by a radiation-resistant cell population in the brain. (a) Survival curves of chimeric B6.Ly5.1 mice engrafted with BM from C57BL/6 (solid line), B6.TNFα^−/− (overlapping C57BL/6 mice and indicated by arrow), B6.LTα^−/− (dashed line), and B6.TNF/LTα^−/− (dotted line) mice infected with P. berghei. Results represent pooled data from three independent groups of mice (n = 4–6 per group) in experiments conducted on three separate occasions (total of n = 12–16 mice per group). Differences in survival between B6.Ly5.1 mice engrafted with BM from C57BL/6 or B6.TNFα^−/− mice and mice deficient in LTα were statistically different (χ² = 7.01, P < 0.01), as was the difference between mice engrafted with BM from B6.LTα^−/− and B6.TNF/LTα^−/− mice (χ² = 23.83, P < 0.0001). (b) LTα mRNA is detected by real-time RT-PCR in the brain of all chimeric B6.Ly5.1 mice following P. berghei infection (brain tissue collected at time of death). The source of engrafted BM is indicated. (c) Survival curve of chimeric B6.Ly5.1 mice engrafted with BM from C57BL/6, B6.TNFα^−/− or B6.LTα^−/− mice (all groups overlap; solid line), and chimeric B6.TNF/LTα^−/− mice engrafted with BM from C57BL/6 (dotted line), B6.TNFα^−/− (dashed line), or B6.LTα^−/− (dashed and dotted line) mice (n = 4 per group). Differences in survival between B6.Ly5.1 mice engrafted with BM from C57BL/6 and B6.TNF/LTα^−/− mice engrafted with BM from C57BL/6, B6.TNFα^−/−, or B6.LTα^−/− mice were statistically different (χ² = 15, P < 0.0001), as was the increased survival time of B6.TNF/LTα^−/− mice engrafted with BM from B6.TNFα^−/− mice over all other groups (χ² = 6.628, P < 0.01).