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. 2003 May 19;197(10):1297–1302. doi: 10.1084/jem.20030016

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — Comparison of CIA symptoms in female wild-type and cPLA₂α-deficient mice. (A) Disease severity scores of arthritis for each group of animals (n = 12 for cPLA₂α^−/− and n = 17 for cPLA₂α^+/+). Significant differences to the wild-type group are marked with ** for P < 0.01 and * for P < 0.05 (two-tailed t test). (B) Percentage of female, wild-type, and cPLA₂α-deficient mice that developed arthritis in >1 digit. Of the cPLA₂α-deficient mice that developed arthritis, the disease was limited to 1 digit or less. In comparison, 16 out of 17 wild-type mice developed arthritis in >1 digit. Significant differences to the wild-type group are marked with *** for P < 0.0001, ** for P < 0.001, and * for P < 0.05 (Fisher's exact test). The results are from a single representative experiment.