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. 2003 Jan 6;197(1):63–75. doi: 10.1084/jem.20021638

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Effect of Tat-CT on TNF-triggered neutrophil degranulation. Neutrophils were incubated as indicated (test proteins were added at 500 nM) and their supernate was assayed for the presence of lactoferrin (LF) as a measure of specific granule release and myeloperoxidase (MPO) for azurophil granule release. LDH was measured as an indicator of spontaneous cell lysis. Specific LF (A) and MPO (B) release (corrected for cell lysis) are shown normalized to that seen with TNF alone in the absence of ovalbumin (ova) or Tat-CT. TNF alone led to the specific release of an average of 67 and 27% of total detergent-releasable LF and MPO content of the cells, respectively, over and above the mean 5% release that could be attributed to cell death. Results are the mean ± SEM in three independent experiments for LF release and two for MPO release.