Table 1.

CB1 receptor, neuropeptide, and GAD 67 mRNA expression in striatum and nucleus accumbens of CB1^+/+ and CB1 ^−/− mice

		CB1	Dynorphin		Substance P		Enkephalin		GAD 67
		+/+	+/+	−/−	+/+	−/−	+/+	−/−	+/+	−/−
NAC	Shell	1.9  ±  0.6	61.8  ±  2.7	64.9  ±  2.6	104.8  ±  2.1	94.6  ±  1.0***	64.9  ±  2.2	57.3  ±  3.2	69.6  ±  1.2	71.1  ±  1.1
	Core	2.7  ±  0.4	53.7  ±  1.4	54.3  ±  2.9	49.7  ±  3.0	42.7  ±  2.0	70.2  ±  4.4	63.4  ±  3.8	51.1  ±  1.7	53.2  ±  1.2
S, rostral	Medial	7.0  ±  0.4	22.9  ±  1.4	25.7  ±  1.4	53.7  ±  1.1	55.0  ±  1.3	58.1  ±  1.7	63.6  ±  1.8*	48.8  ±  1.2	54.6  ±  0.8**
	Central	23.1  ±  1.7	10.9  ±  1.0	18.0  ±  1.7**	50.5  ±  1.6	53.8  ±  1.0	64.3  ±  1.9	65.6  ±  1.2	55.1  ±  1.3	57.6  ±  0.5
	Lateral	50.4  ±  2.3	12.6  ±  1.3	18.8  ±  1.3**	57.3  ±  2.6	62.3  ±  2.0	69.9  ±  1.4	72.7  ±  1.5	59.8  ±  1.2	64.4  ±  0.7**
S, middle	Medial	12.0  ±  0.4	21.5  ±  1.8	23.8  ±  1.8	43.5  ±  1.3	48.1  ±  1.7	58.6  ±  1.5	65.6  ±  1.0**	44.3  ±  0.9	50.0  ±  0.8***
	Central	40.5  ±  1.4	4.5  ±  0.3	8.3  ±  0.7***	37.1  ±  0.8	44.9  ±  1.0***	64.4  ±  2.4	71.4  ±  1.3*	48.8  ±  1.1	53.9  ±  0.9**
	Lateral	74.1  ±  1.2	5.9  ±  0.3	13.4  ±  1.3***	50.7  ±  1.4	61.3  ±  1.9***	68.7  ±  2.3	76.4  ±  0.8**	61.5  ±  1.2	71.7  ±  1.6***
S, caudal	Medial	4.7  ±  1.1	29.4  ±  2.5	32.8  ±  1.1	42.9  ±  1.4	43.9  ±  1.6	54.2  ±  1.4	58.8  ±  2.0	41.6  ±  1.2	45.4  ±  1.6
	Central	26.6  ±  3.7	8.0  ±  1.6	15.3  ±  1.2**	38.0  ±  1.8	42.9  ±  1.4	57.8  ±  2.6	61.7  ±  1.3	41.8  ±  1.4	48.6  ±  1.2**
	Lateral	49.2  ±  3.7	11.2  ±  1.7	18.7  ±  1.2**	46.7  ±  1.4	52.9  ±  1.3**	67.5  ±  2.0	74.8  ±  1.4*	44.7  ±  0.8	52.4  ±  1.7**

Data presented are mean density values (mean ± SEM) measured in CB1^+/+ (n = 7) and CB1^−/− mice (n = 7). NAC, nucleus accumbens; S, striatum.  

²⁰⁹, P < 0.001;  

²⁰⁸, P < 0.01;  

¹⁷⁸, P < 0.05.