Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2003 Mar 3;197(5):601–614. doi: 10.1084/jem.20021945

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2003, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — A model linking two different CW3-specific αβ TCR clones to the same, ancestral VDJ-β precursor. At the top of the figure, T cell development in the thymus is schematized for the CD4⁻CD8⁻ (DN) to CD4⁺CD8⁺ (DP) stages, showing the progressive changes in surface expression of CD44 and CD25 that define the DN1 to DN4 stages. The stages at which different TCR gene rearrangements occur are indicated, with potential stages for continued D to J recombination shown in parentheses. The lower part shows our model for the rearrangements at the different TCR loci on both chromosomes (arbitrarily designated a or b) at different stages of development for the two clones from M-42 that share the Vβ10Dβ1Jβ1.2-2i and Dβ1Jβ1.4 rearrangements shown in Fig 4. The cell making the ancestral VDJ-β rearrangement that is shared by all progeny is indicated with *. Potential (?) additional progeny expressing other TCR-α and/or Dβ2Jβ2 rearrangements are also shown.