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. 2003 Mar 3;197(5):615–624. doi: 10.1084/jem.20021426

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — PAI-1 activity 1 d after AMI in WT and MPO^−/−. (A) Representative reverse casein zymograms for PAI-1 activity in protein extracts from the infarct zones of two representative WT and two MPO^−/− mice with no MI (filled bars) or one representative MPO^−/−. (B) PAI-1 activity in WT and MPO^−/− 1 d after AMI (open bars) as quantified in arbitrary units from reverse zymograms (n = 4 animals per group per time point). *, P < 0.02, WT versus MPO^−/− 1 d after AMI. (C) Inhibition of PAI-1 activity (%) in the infarct zone relative to PAI-1 activity in strain-matched non-infarcted tissue as measured by two-stage indirect plasmin-based assay for PAI-1 in WT (n = 6) and MPO^−/− (n = 6) myocardium 1 d after LAD ligation. Data represent mean ± SD. *, P < 0.01.