Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2003 Feb 17;197(4):537–542. doi: 10.1084/jem.20021850

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2003, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — TLR-4 ligand stimulation circumvents requirement for IL-1R signaling. Adult K/BxN mice were bled and the sera pooled. Adult were injected with 100 μl of pooled sera intraperitoneally on days 0 and 2. In addition, some groups also received an injection of 50 μg LPS intraperitoneally on day 0. C57Bl/6 mice treated with sera are presented as a positive control in each experiment. (A and B) C57Bl/6 treated with sera (closed circle), and LPS and sera (open circle); (C and D) C57Bl/6 treated with sera (closed circle) and IL-1R^−/− mice treated with sera and LPS (open square); and (E and F) C57Bl/6 treated with sera (closed circle), MyD88^−/− mice treated with LPS and sera (open triangle) and sera alone (closed triangle). Arthritis was clinically scored and ankle thickness was measured with a caliper. The means of 3–4 mice per group ± SEM are shown.