Table I.
Incidence of MC57 Tumors in Experiments
| Treatment
|
||||
|---|---|---|---|---|
| Mice | Tumor injected | 2C | Tumor incidence (%)a | 2C priming |
| CD8−/− | MC57G | 6/6 (100) | ||
| EGFP | 6/6 (100) | |||
| Ld | 12/12 (100) | |||
| SIY | 12/12 (100) | |||
| MC57G | Yes | 6/6 (100) | No | |
| EGFP | Yes | 6/6 (100) | No | |
| Ld | Yes | 12/12 (100) | No | |
| SIY | Yes | 0/12 (0) | Yes | |
| Ldw/SIYb | Yes | 0/9 (0) | Yes | |
| Ldw/EGFPb | Yes | 6/6 (100) | No | |
| MC57Gw/SIYb | Yes | 6/6 (100) | No | |
| CD4 depletion
|
||||
| WT | MC57G | 0/6 (0) | ||
| EGFP | 0/6 (0) | |||
| Ld | 0/6 (0) | |||
| SIY | 0/12 (0) | |||
| SIY | Yes | 0/12 (0) | ||
| Splenectomized WTc | SIY | 0/9 (0) | ||
| Splenectomized LT−/− c | SIY | 0/9 (0) | ||
| LT−/−-WT BM chimera | SIY | 0/6 (0) | ||
| Splenectomized LT−/−-WT BM chimerac |
SIY | 0/3 (0) | ||
| LT−/− | SIY | 0/12 (0) | ||
| SIY | Yes | 9/9 (100) | ||
| LN-less WT | SIY | 0/9 (0) | ||
| SIY | Yes | 6/6 (100) | ||
| Splenectomized LN-less WTc |
SIY | 0/3 (0) |
a
The number in parentheses reflects the pooled experiments with three mice per group.
b
Mice were challenged with tumor indicated on opposite flanks.
c
Splenectomized mice were used in the experiment at least 10 days after surgery.