Table I.
Microbial Analysis of Skin from HPV16 Mice
| Genotype | Staphylococcus aureus | Staphylococcus epidermidis |
|---|---|---|
| HPV16 | ++++ | ++++ |
| HPV16 | ++++ | ++++ |
| HPV16 | ++++ | ++ |
| HPV16/CD4−/− | +++ | − |
| HPV16/CD4−/− | +++ | − |
| HPV16/CD4−/− | +++ | − |
| NTg | + | − |
| NTg | + | + |
| NTg | + | + |
Ear and chest skin from normal non-transgenic FVB/n (NTg) and HPV16 mice between 8 and 12 mo of age was removed under sterile conditions and submitted to IDEXX Veterinary Services (Sacramento, CA) for identification and quantification of aerobic bacteria present within the tissue by semiquantitative limiting dilution analysis. Results shown are from ear skin in which both Staphylococcus aureus and Staphylococcus epidermidis were detected. The data shown is on a scale of one to four (+). All other aerobic microbial species were one (+) or lower. Equivalent infection was observed in chest skin.