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. 2003 Apr 21;197(8):955–966. doi: 10.1084/jem.20021024

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — Epitope mapping of a superagonistic (JJ316) and conventional (JJ319) rat CD28-specific mAb. (A) Comparison of extracellular portions of mouse and rat CD28. Positions of aa differences are indicated by numbers. (B) Binding of superagonistic and conventional mAbs to rat/mouse CD28 chimeras. Mouse sequences are represented in white and rat sequences in black. Positions of swapped aa are indicated on the left. All constructs were stably expressed in L929 fibroblast cells. FACS^® histograms are shown for superagonistic (JJ316) and conventional (JJ319) rat and for the conventional mouse CD28-specific mAb 37.51 (solid lines) and an isotype-matched control mAb (dotted lines). At least two independent experiments were performed and a representative experiment is shown.