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editorial

. 2003 Apr 21;197(8):949–953. doi: 10.1084/jem.20030303

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — Location of sites of interaction of CD80 (B7-1) and CD86 (B7-2) and of superagonist mAbs mapped to the surface of CD28. The structure of CD28 as a disulfide-linked Ig-like homodimeric domain on the surface of the T cell is illustrated schematically, depicting interactions with either the monomeric B7-2 or the homodimeric B7-1. The surface exposure the MYPPPY loop that has been shown crystallographically to interact with both B7-2 and B7-1 is colored red and the C”D loop that interacts with the superagonistic antibodies is shown in yellow. The cytoplasmic carboxylterminus of CD28 is indicated and the potential phosphorylation site(s) is indicated as a green circle.