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. 2003 Apr 21;197(8):1059–1063. doi: 10.1084/jem.20030240

Figure 2.

Figure 2.

TSLP-activated DCs induce IL-5 and IL-13–producing CD8+ T cells. Cytokine production by naive CD8+ T cells primed for 6 d with medium-DCs, CD40L-DCs, TSLP-DCs, or TSLP+CD40L-DCs. Harvested CD8+ T cells were restimulated for 24 h with anti-CD3 and anti-CD28 and IFN-γ, TNF-α, IL-4, IL-5, IL-10, and IL-13 were measured in the culture supernatant by ELISA. TSLP-DCs and TSLP+CD40L-DCs both induced IL-5 and IL-13 producing CD8+ T cells. However, in contrast to TSLP-DCs, TSLP+CD40L-DCs primed CD8+ T effector cells to produce high levels of IFN-γ. Data represent one of three independent experiments.