Table I.
Frequency of B Cells, Memory B Cells, and IgM Memory B Cells in CVID Patients
| Patients | Age(years) | PercentB cells | PercentCD27+
B cells |
PercentIgM memory | Infections byencapsulatedbacteria |
|---|---|---|---|---|---|
| 1 | 24 | 8.7 | 2.12 | undetectable | yes |
| 2 | 20 | 17.1 | 3.5 | undetectable | yes |
| 3 | 27 | 7.2 | 3.3 | undetectable | yes |
| 4 | 32 | 14.92 | 8 | 94.5 | no |
| 5a | 43 | 8.4 | 72.7 | 88.8 | no |
| 6a | 51 | 11.9 | 53 | 85.4 | no |
All patients were diagnosed as having CVID and received intravenous Ig treatment. Percent of B cells was calculated in the lymphocyte gate, percent of CD27+ B cells was calculated considering B cells as 100% positive, and percent of IgM memory B cells was calculated considering the CD27+ B cells as 100%.
a
These patients have a major T cell defect.