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. 2003 Apr 7;197(7):823–829. doi: 10.1084/jem.20021840

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — Cytofluorometry of DV infection of DC-SIGN–expressing cells. (A) The MFI of DC-SIGN surface expression on DC and THP-1 cells is shown (left). The bars represent means (± SEM) of at least three independent experiments. The top right histogram shows the relative DC-SIGN expression (MFI) on a representative donor's immature (shaded) and MCM-matured DCs (heavy line). The bottom right histogram shows relative DC-SIGN on the surface of THP DC-SIGN (shaded) and THP-1 cells (heavy line). Matched isotype controls are represented by the light dashed line. (B) The mean (± SEM) percentage of DV infection of immature and mature DC (left) and THP DC-SIGN and THP-1 (right) after intracellular staining for dengue envelope antigen (2H2) in at least three independent experiments. (C) Positive correlation between DC-SIGN expression (MFI) on the x axis and percent DV infection as determined by 2H2 binding on the y axis on both DC and THP cells (n = 16).