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. 2003 Jun 16;197(12):1755–1765. doi: 10.1084/jem.20021659

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Extravasated eEPCs branch and interconnect tumor blood vessels. (A and D) Tumor microvasculature after contrast enhancement by FITC-dextran. (B and E) Same regions of interest as in A and D, demonstrating DiI-labeled eEPCs. (C and F) Superimposed FITC and DiI images after adding false colors to DiI images. eEPCs are marked with green false color. (A–C) eEPCs participate in angiogenic sprouting (arrow indicates vascular sprout; day 1 after injection). (D–F) eEPCs branch and span between individual tumor blood vessels interconnecting distant microvascular segments (arrows indicate vascular sprouts; day 1 after injection).