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. 2003 Jun 16;197(12):1645–1655. doi: 10.1084/jem.20030239

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Virus replication and intrahepatic immune responses following antibody-mediated depletion of CD8⁺ T cells. (A) CD4⁺ and CD8⁺ T cell subsets were monitored in the blood of CB0556 (top panel) and CB0572 (bottom panel) after three doses of cMT-807 (vertical dashed lines). Anti-CD3 expanded CD8⁺ T cells from the liver of CB0556 (B) and CB0572 (C) were tested for IFN-γ production in an ELISPOT assay using HCV-1 peptide pools and individual epitopes. * Indicates inability to recover and expand CD8⁺ T cells from liver tissue until days 42 and 28 after infection from CB0556 (B) and CB0572 (C), respectively. (NS) indicates that no liver sample was obtained from either chimpanzee on day 35 after infection.