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. 2003 Jun 16;197(12):1635–1644. doi: 10.1084/jem.20030215

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Cells mediating GAD65-specific tolerance. (A) NOD mice were lethally irradiated and reconstituted with bone marrow from NOD (open bars) or GAD65tg. mice (gray bars). Proliferative recall responses after immunization with GAD65. CF, culture filtrate protein of M. tuberculosis as positive control. Representative result out of three independent experiments. (B) Thymectomized NOD mice were engrafted with E14 fetal thymi from NOD (open bars) or GAD65tg. mice (gray bars) and, after ablative irradiation, reconstituted with NOD bone marrow. Proliferative recall responses after immunization with GAD65.

Figure 4. — Cells mediating GAD65-specific tolerance. (A) NOD mice were lethally irradiated and reconstituted with bone marrow from NOD (open bars) or GAD65tg. mice (gray bars). Proliferative recall responses after immunization with GAD65. CF, culture filtrate protein of M. tuberculosis as positive control. Representative result out of three independent experiments. (B) Thymectomized NOD mice were engrafted with E14 fetal thymi from NOD (open bars) or GAD65tg. mice (gray bars) and, after ablative irradiation, reconstituted with NOD bone marrow. Proliferative recall responses after immunization with GAD65.