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. 2003 May 5;197(9):1073–1081. doi: 10.1084/jem.20021603

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Suboptimal immunization protocols trigger optic neuritis but not EAE in 2D2 TCR transgenic mice. 2D2 TCR transgenic mice were immunized with 100 μg MOG 35–55 peptide emulsified in CFA and injected with pertussis toxin, immunized with 10 or 100 μg of the MOG 35–55 peptide alone, or injected with pertussis toxin only. The proportion of mice developing EAE or optic neuritis was evaluated by histological analysis of brains, spinal cords, and optic nerves. The number of mice developing EAE or optic neuritis in each group is indicated in parentheses on the right side of the histogram bar.