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. 2003 May 5;197(9):1107–1117. doi: 10.1084/jem.20021787

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — Dectin-1 stimulates production of ROS in macrophages. (a) Production of ROS was assayed by luminol-enhanced chemiluminescence in RAW cells in the presence of 100 μg/ml zymosan together with the indicated concentrations of laminarin. (b) Zymosan-induced production of ROS in RAW cells was compared with RAW cells overexpressing wild-type dectin-1 in the presence or absence of 500 μg/ml laminarin. (c) Zymosan-induced production of ROS in RAW cells was compared with RAW cells overexpressing a signaling-deficient (Δ38) form of dectin-1. (d) Zymosan-induced production of ROS was measured in RAW cells overexpressing wild-type dectin-1 with or without 4 h prestimulation with 100 ng/ml LPS or 100 ng/ml PAM₃CSK₄ lipopeptide.