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. 2003 May 5;197(9):1125–1139. doi: 10.1084/jem.20020552

Figure 8.

Figure 8.

Effect of Bcl-2 overexpression on SpA-induced B cell deletion. The outcome of in vivo treatments with SpA or a control protein are depicted for Bcl-2 transgenic (TgN(Bcl-2)22) and BALB/c mice. When evaluated ex vivo, 16 h after treatment, SpA exposure greatly decreases the representation of detectable SpA-reactive B cells in either strain of mice. After subsequent in vitro culture, SpA exposure results in the deletion of most of the SpA-reactive BALB/c B cells whereas comparable deletion does not occur in the Bcl-2 transgenic B cells. Analyses were performed on groups of OVA-treated BALB/c mice (n = 5), SpA-treated BALB/c mice (n = 6), OVA-treated Bcl-2 transgenic mice (n = 5), and SpA-treated Bcl-2 transgenic mice (n = 4).