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. 2003 May 5;197(9):1125–1139. doi: 10.1084/jem.20020552

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Copyright © 2003, The Rockefeller University Press

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Figure 9. — Mechanisms of death induced by a B cell superantigen. Encounter of susceptible B cells with pentameric natural SpA is mediated by a nonimmune interaction with BCR that include clan III V_H regions. (1) During the initiation phase, this encounter results in down-regulation of BCR and the coreceptors that include CD19 and CD21, and the induction of activation markers (not depicted). (2) A decision phase, lasting many hours follows subsequently, during which B cells might be rescued by second signal. (3) The degradation phase is presumably mediated by the apoptosome, with release of cytochrome C, and eventually leading to the apoptotic caspase-dependent death pathways.