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. 2003 May 5;197(9):1153–1163. doi: 10.1084/jem.20021761

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Copyright © 2003, The Rockefeller University Press

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Figure 7. — RIPLTαβ-HEV show increased luminal PNAd and HEC-6ST expression. RIPLTα (top panel) and RIPLTαβ (bottom panel) pancreatic tissue sections were analyzed by two-color immunofluorescence analysis with MECA 79 (red) and anti-HEC-6ST (green) antibodies. The H&E stained image was merged with MECA 79 staining to orient the histologic location of the vessels; objective 20×. RIPLTα infiltrates exhibited predominately abluminal MECA 79⁺ staining vessels and no detectable HEC-6ST expression similar to LTβ^−/− MLN-HEV (Fig 6, bottom panel). In contrast, analysis of RIPLTαβ pancreata revealed both luminal and abluminal MECA 79⁺ vessels with coincident HEC-6ST expression on those luminal, pericellular MECA 79⁺ HEV. Bottom panel inset of RIPLTαβ HEV demonstrates intracellular HEC-6ST expression and cell surface PNAd expression–a pattern more reminiscent of C57BL/6 PLN (Fig 6, top panel) than RIPLTα infiltrates. Objective 40×.