TABLE 2.
Level of tolerance | CheY position | Substitutions giving
|
|
---|---|---|---|
Some CW activity (reference or source) | No CW activity (reference or source) | ||
Tolerant | Asp13 | Arg (7) | Ala, Cys, Gln, Gly, His, Leu, Phe, Tyr (7) |
Lys (8) | Glu (8) | ||
Asn, Met, Ser, Thr (32) | |||
Phe14 | His, Arg (Table 1) | Asp, Glu, Lys (Table 1) | |
Tyr (7) | |||
Leua | |||
Trp58 | Arg, His, Lys (Table 1) | Asp, Glu (Table 1) | |
Ile, Pheb | |||
Asn59 | Arg, His, Lys (Table 1) | Asp, Glu (Table 1) | |
Ala (38) | |||
Gln, Sera | |||
Met60 | His (Table 1) | Asp, Glu, Lys, Arg (Table 1) | |
Pro61 | Arg, Lys (Table 1) | Asp, Glu, His (Table 1) | |
Ser, Thra | |||
Glnb | |||
Partially tolerant | Asp12 | Glu (8) | Arg, His (Table 1) |
Gly (7) | |||
Asn, Lys (8) | |||
Alab | |||
Thr87 | Ala, Cys, Ser (3) | Arg, Asp, His (Table 1) | |
Glu, Lys (3) | |||
Ile (13) | |||
Glya | |||
Intolerant | Met17 | Arg, Asp, Glu, His, Lys (Table 1) | |
Ser, Thra | |||
Glnb | |||
Asp57 | Arg, His (Table 1) | ||
Ala, Gln, Leu, Ser (7) | |||
Asn, Glu, Lys (8) | |||
Cys (36) | |||
Val86 | Arg, Asp, Glu, His, Lys (Table 1) | ||
Ala88 | Arg, Asp, Glu, His, Lys (Table 1) | ||
Met, Vala | |||
Glnb | |||
Lys109 | Asp (Table 1) | ||
Cys, Gln, Glu, Gly, His, Leu, Met, Phe, Pro, Ser, Thr, Tyr, Val (7) | |||
Arg (27) |
J. G. Smith et al., unpublished data.
R. B. Bourret, unpublished data.