Table II.
Tumors in Nude Mice
| Cell line | Tumor size (cm) | cm3 |
|---|---|---|
| NIH-3T3 | ND | |
| NIH-3T3-core | ND | |
| WT-STAT3 | ND | |
| WT-STAT3/core | ||
| Clone 1 | 0.8 × 0.8 × 1.0 | 0.64 |
| 0.4 × 0.5 × 0.8 | 0.16 | |
| 0.8 × 0.6 × 0.8 | 0.38 | |
| Clone 2 | 1.8 × 1.5 × 1.5 | 4.05 |
| 1.6 × 1.2 × 1.2 | 2.34 | |
| 1.2 × 1.0 × 1.0 | 1.20 | |
| STAT3-C | 1.2 × 0.8 × 1.0 | 0.96 |
| 1.2 × 1.5 × 1.6 | 2.88 | |
| 1.8 × 1.2 × 1.0 | 2.16 | |
| v-src | 3.0 × 4.0 × 2.5 | 30.0 |
Cells (106) from NIH-3T3, v-src, STAT3-C, and WT-STAT3/core cell lines were injected into the flank of athymic nude mice. Each cell line was determined in 2–3 different mice. Tumor size was determined 3 wk after injection. ND, not detected.