Table I.
PUUV N-specific CD8+ CTL Lines
| Donor | CTL line | Epitope | HLA restrict. | PUUV | % Specific lysisa HTNV V | SNV N |
|---|---|---|---|---|---|---|
| 1 | 1A-C11 | N204-12 | A2 | 44.7 | −1.1 | −1.1 |
| 1A-D10 | N204-12 | A2 | 41.5 | −1.2 | −3.3 | |
| 1A-E5 | N204-12 | A2 | 49.6 | −5.6 | −3.8 | |
| 1B-C3 | N204-12 | A2 | 50.6 | −1.7 | −1.4 | |
| 3-C3 | N204-12 | A2 | 36.4 | −2.8 | −3.9 | |
| 3-D10 | N204-12 | A2 | 56.3 | −4.6 | −6.6 | |
| 3-E4 | N204-12 | A2 | 41.4 | −6.9 | −8.2 | |
| 3-E11 | N204-12 | A2 | 43.4 | −3.0 | −6.7 | |
| 10-B10 | N204-12 | A2 | 37.6 | −2.8 | −3.9 | |
| 1 | 3-C8 | N173-81 | B7 | 18.0 | −7.8 | −3.7 |
| 10-F5 | N173-81 | B7 | 33.6 | 25.5 | 0.5 | |
| 10-G4 | N173-81 | B8 | 22.4 | 2.7 | −1.8 | |
| 1 | 1A-G6 | N243-51 | B8 | 76.7 | ND | ND |
| 2 | 1A-D11 | N236-50 | ND | 19.1 | −1.0 | 2.2 |
| 1B-G9 | N236-50 | ND | 20.3 | −1.8 | 22.0 | |
| 3-B2 | N236-50 | ND | 19.3 | −0.3 | 3.2 | |
| 3-E9 | N236-50 | ND | 24.0 | 3.1 | 2.2 | |
| 10-B4 | N236-50 | ND | 18.2 | 2.0 | 2.7 | |
| 10-B5 | N236-50 | ND | 17.9 | 0.9 | 3.8 | |
| 10-E11 | N236-50 | ND | 20.8 | 2.6 | 1.7 | |
| 2 | 3-D3 | N212-20 | ND | 27.3 | −1.7 | −3.5 |
| 3-D3 | N212-20 | ND | 27.6 | 0.4 | 1.9 | |
| 2 | 3-B8 | N164-78 | A28 | 27.4 | 25.9 | −3.0 |
E/T = 10.