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. 2002 Sep 2;196(5):629–639. doi: 10.1084/jem.20011693

Figure 4.

Figure 4.

In vitro induction of somatic hypermutation. CLL 136 and CLL 216 did not exhibit evidence of in vivo intraclonal diversity (see Table I). After in vitro stimulation, 3 of 32 VHDJH transcripts in CLL 136 and 5 of 34 in CLL 216 displayed gel mobilities different from that of corresponding transcripts obtained from the unstimulated CLL cells. Transcripts were sequenced and each contained at least one nucleotide change.