Table I.

Ig V_HDJ_H Genes and Somatic Point-Mutations Expressed in CLL B Cells

						Point mutations
CLL case	GenBank accession number	VH gene	D gene	JH gene	Number of transcripts analyzed	Total	Shareda	Partiallysharedb	Uniquec	Number of mutations expected by PCR error
63	AF021974	1-46	D6-6	JH6b	29	0	0	0	0	0.29
67	AF021990	4-34	D2-15	JH4b	24	0	0	0	0	0.24
270	AY055487	1-02	D6-19 + D3-9	JH4b	28	1	0	0	1	0.28
141	AF022005	4-34	D2-2	JH5b	29	2	0	0	2	0.29
156	AY055478	1-45	D2-2 + D3-10	JH5b	27	2	0	0	2	0.27
7	AY055477	3-49	D3-3	JH5a	29	2	2	0	0	0.29
258	AY05485	1-69	D3-16	JH3b	30	3	0	0	3	0.30
216	AY055483	3-49	D5-12	JH6b	40	3	3	0	0	0.40
48	AF0211969	1-02	D6-13	JH3b	26	8	8	0	0	0.26
175	AY055484	3 (HHG4)	D3-16	JH6b	28	9	2	0	7	0.28
249	AY055479	3-23	D2-21	JH4b	30	10	4	0	6	0.30
165	AY055482	3-15	D1-26	JH6b	30	14	14	0	0	0.30
178	AY055482	2-05	ND	JH4b	30	17	13	0	4	0.30
136	AF022002	4-34	D2-2	JH6b	40	18	18	0	0	0.40
113	AF021989	2-05	ND	JH4b	57	24	21	0	3	0.57
169	AY055480	3-33	D3-9	JH4b	50	26	24	0	2	0.50
261	AY055486	3-33	D5-12	JH4b	80	36	14	8	14	0.80
105	AF021986	3-23	D2-21	JH4b	60	40	5	11	24	0.60

Point-mutations in the Ig V_HDJ_H gene transcripts of CLL B cells.

^aShared, mutations shared by all the Ig V_HDJ_H gene transcripts analyzed.

^bPartially shared, mutations shared but some but not all the Ig V_HDJ_H gene transcripts analyzed.

^cUnique, mutations unique to distinct Ig V_HDJ_H gene transcripts analyzed.

Based on error rate of 10⁻⁶ change/base/PCR cycle.