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. 2002 Jul 1;196(1):97–108. doi: 10.1084/jem.20020298

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Copyright © 2002, The Rockefeller University Press

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Figure 6. — Reversal of antigen-induced B7h down-regulation is specific to CD40 signaling. (A) Cytokines and LPS do not prevent antigen-induced B7h down-regulation. Purified B cells were activated with soluble HEL antigen and the indicated treatments. After 48 h of stimulation, cells were stained for B7h expression. Relative B7h expression was determined as the ratio of mean B7h fluorescence intensity on experimental to unstimulated B cells. (B) CD40 signaling does not prevent B7h down-regulation by anti-IgM cross-linking. B cells from transgenic and nontransgenic mice were activated with anti-IgM F(ab′)₂ in the presence or absence of anti-CD40 mAb. After 48 h, cells were stained for B7h expression.