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. 2002 Oct 7;196(7):957–968. doi: 10.1084/jem.20021052

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Copyright © 2002, The Rockefeller University Press

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Figure 1. — Kinetics of expansion and recruitment of in vivo generated effectors. 5 × 10⁶ naive CFSE-labeled, CD4 T cells from HNT.Thy1.1 mice, were transferred into normal BALB/c hosts. Recipient mice were infected intranasally with 0.5 LD₅₀ of A/PR8/34 (PR8, H1N1) influenza A virus 1 d later. At the indicated time points after infection, mice were killed and spleen, a pool of nondraining LN (pLN), MLN, lungs, and BAL were harvested. The total number of cells and percentage of CD4⁺Thy1.1⁺ (donor cells) was calculated. (A) Absolute cell numbers of donor cells in the organs indicated over time after influenza infection calculated using the percentages in B. Each bar represents three individual mice per group and is representative of three independent experiments. (B) The percentages of donor cells obtained from each organ. (C) The virus titer in the lungs of BALB/c mice from day 2 to 8. Data represent mean titers from lungs of three individual mice analyzed per time point.