Figure 2.

Platelet adhesion precedes leukocyte chemotaxis. (A) Photomicrographs show frozen sections immunostained for VCAM-1 in the time course of atherogenesis (original magnification: 200-fold). (B) Leukocyte adhesion to the endothelium of the common carotid artery was assessed by fluorescence microscopy as described previously (reference 5). The right panel shows representative in vivo fluorescence microscopy images at distinct time points; the data are summarized in the left panel. White arrows indicate adherent leukocytes. Mean ± SEM, n = 10 each group. *P < 0.05.