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. 2002 Oct 7;196(7):887–896. doi: 10.1084/jem.20012044

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — Platelet membrane glycoproteins GPIbα and GPIIb-IIIa mediate platelet–endothelium adhesion in the common carotid artery of ApoE ^−/− mice. (A) Platelets were preincubated with blocking mAbs (50 μg/ml) directed against GPIbα (p0p/B-Fab) or GPIIb-IIIa (JON/A-F(ab)₂ before they were administered into ApoE ^−/− mice (10-wk-old). Platelet–endothelial cell interactions were investigated by in vivo fluorescence microscopy (see Materials and Methods). The top panel shows representative photomicrographs, the bottom panel summarizes the data (mean and SEM) of n = 4 experiments. *P < 0.05. (B) Platelets isolated from a Glanzmann's patient with a functional defect in the GPIIb-IIIa receptor (reference 6) or from a healthy control individual were evaluated for platelet–endothelium adhesion in ApoE ^−/− mice. n = 4, mean ± SEM. *P < 0.05.

Figure 3. — Platelet membrane glycoproteins GPIbα and GPIIb-IIIa mediate platelet–endothelium adhesion in the common carotid artery of ApoE ^−/− mice. (A) Platelets were preincubated with blocking mAbs (50 μg/ml) directed against GPIbα (p0p/B-Fab) or GPIIb-IIIa (JON/A-F(ab)₂ before they were administered into ApoE ^−/− mice (10-wk-old). Platelet–endothelial cell interactions were investigated by in vivo fluorescence microscopy (see Materials and Methods). The top panel shows representative photomicrographs, the bottom panel summarizes the data (mean and SEM) of n = 4 experiments. *P < 0.05. (B) Platelets isolated from a Glanzmann's patient with a functional defect in the GPIIb-IIIa receptor (reference 6) or from a healthy control individual were evaluated for platelet–endothelium adhesion in ApoE ^−/− mice. n = 4, mean ± SEM. *P < 0.05.