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. 2002 Oct 7;196(7):877–886. doi: 10.1084/jem.20020178

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Copyright © 2002, The Rockefeller University Press

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Figure 4. — CD8 cells from CD103^−/− mice exhibit normal responsiveness to A/J alloantigens in conventional assays of CD8 effector function. CD8 effectors were generated by coincubation of SCs from CD103^+/+ or CD103^−/− mice with A/J SCs in 5-d mixed lymphocyte cultures, and purified by negative selection with mAb plus complement. (A) IFN-γ production by CD8 effectors derived from CD103^+/+ (black circles) or CD103^−/− (white circles) in response to A/J SCs or media only (triangles). Data shown are means (±SE) of three replicate values. (B) Lytic activity of CD8 effectors derived from CD103^+/+ (circles) or CD103^−/− (triangles) to A/J (black symbols) and BALB/c (white symbols) lymphoblast targets in standard 4-h ⁵¹[Cr] release assays. Data shown are means of four replicate values; SD was <10% of mean values.