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. 2002 Sep 16;196(6):731–741. doi: 10.1084/jem.20020223

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — Effect of V_H minigene vaccination on lupus nephritis and survival. 3-mo-old BWF1 mice were vaccinated with pCD.III (▴), pCD (▪), or PBS (⋄), as described in Fig. 4 (n = 14 mice per group pooled from two experiments). The percent cumulative incidence of severe (≥300 mg/dl) proteinuria and survival are shown in A and B, respectively. P < 0.01 to < 0.001 by log rank test in pCD.III-vaccinated versus pCD- or PBS-injected mice; P = NS in pCD versus PBS groups. (C) Representative H+E– or PAS-stained renal sections from BWF1 mice inoculated with PBS (left panels) or pCD.III (right panels). Kidneys were harvested at the age of 40 wk, or before in mice that had terminal disease. Findings were similar in the two control groups (PBS and pCD) of mice, which had severe glomerular sclerosis (GSc), interstitial infiltrates (INF), fibrous and cellular crescents (CRE), and tubular atrophy (TA). In contrast, the pCD.III-vaccinated mice had only mild glomerular (GP) or mesangial proliferation (MP). Original magnification: ×200 in the top panels and ×400 in bottom panels.

Figure 5. — Effect of V_H minigene vaccination on lupus nephritis and survival. 3-mo-old BWF1 mice were vaccinated with pCD.III (▴), pCD (▪), or PBS (⋄), as described in Fig. 4 (n = 14 mice per group pooled from two experiments). The percent cumulative incidence of severe (≥300 mg/dl) proteinuria and survival are shown in A and B, respectively. P < 0.01 to < 0.001 by log rank test in pCD.III-vaccinated versus pCD- or PBS-injected mice; P = NS in pCD versus PBS groups. (C) Representative H+E– or PAS-stained renal sections from BWF1 mice inoculated with PBS (left panels) or pCD.III (right panels). Kidneys were harvested at the age of 40 wk, or before in mice that had terminal disease. Findings were similar in the two control groups (PBS and pCD) of mice, which had severe glomerular sclerosis (GSc), interstitial infiltrates (INF), fibrous and cellular crescents (CRE), and tubular atrophy (TA). In contrast, the pCD.III-vaccinated mice had only mild glomerular (GP) or mesangial proliferation (MP). Original magnification: ×200 in the top panels and ×400 in bottom panels.