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. 2003 Jul 21;198(2):333–340. doi: 10.1084/jem.20030684

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — SHIP-deficient mice lack MZBs and MZMOs are displaced to the red pulp. (a) FACS^® profiles of single cell suspensions from the spleen of SHIP-heterozygous (SHIP^+/−) and -deficient (SHIP^−/−) mice. MZBs were measured as the CD19⁺, CRI^high, and CD23^low population. The numbers shown represent percent of CD19⁺ cells for the depicted gates as an average of five mice. Numbers for the follicular B cells are shown for comparison. (b) Representative immunohistochemical analysis of above listed mice. At least four serial sections from each mouse were stained for MOMA-1⁺ (blue, top) metallophilic macrophages or MARCO⁺ MZMOs (blue, bottom). Sections were also stained for B220 (brown) to show the positioning of the follicle. ×10.