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. 2003 Jul 21;198(2):281–291. doi: 10.1084/jem.20030645

Figure 1.

Figure 1.

LACK Ag-presenting capacity of CD11c+ and CD11c− cells derived in vivo after immunization. BALB/c mice (20 mice per group) were injected s.c. into four separate sites with PBS, CpG ODN, LACK, or LACK + CpG ODN. CD11c+ and CD11c−cells were isolated 2 d (A) or 7 d (B) later from draining LN. CD11c+ (104; A and B) or CD11c- (105; A and B) were cocultured with LMR 7.5 hybridoma cells (105) for 24 h. IL-2 content was assessed from the supernatants from triplicate wells. (C) In a separate experiment, varying numbers of CD11c+ cells from mice immunized with LACK + CpG ODN were added to LMR 7.5 cells and IL-2 content assessed. Results are expressed as geometric mean ± SEM and are representative of four individual experiments.