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. 2002 Nov 4;196(9):1127–1140. doi: 10.1084/jem.20011247

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Copyright © 2002, The Rockefeller University Press

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Figure 5. — The mitochondrial targeting of M11L is important for inhibition of ΔΨ_m loss induced by the PBR ligands PK11195 and PPIX. (A) Cells expressing EGFP appended with truncated, nontargeted M11L (stop), full length M11L, the mitochondrial targeting sequence (mt), or Bcl-2 were treated with 5 μM staurosporine (STS) or 5 μM staurosporine in combination with 120 μM PK11195 (STS+PK1195). The reduction in the percentage of TMRE-positive EGFP-expressing cells after treatment is shown. The data represent the average of three independent experiments (±SD). (B) Cells expressing EGFP chimeras were treated with 25 or 30 μM PPIX. The reduction in the percentage of TMRE positive EGFP-expressing cells after treatment is shown. The results represent the average of three independent experiments (±SD).