Table III.
TLR5 SNP Allele and Haplotype Frequencies in Cases and Controls
| SNP
|
Cases n = 108 |
All controls n = 508 |
Matched controls n = 89 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | BP | Allele | freq | freq | OR | (95% CI) | P | freq | OR | (95% CI) | P |
| 1. | 1174C | 0 | 0.917 | 0.950 | 0.955 | ||||||
| 1174T | 1 | 0.083 | 0.050 | 1.75 | (1.00, 3.05) | 0.05 | 0.045 | 1.93 | (0.74, 5.03) | 0.18 | |
| 2. | 1775A | 0 | 0.827 | 0.884 | 0.899 | ||||||
| 1775G | 1 | 0.173 | 0.116 | 1.60 | (1.04, 2.45) | 0.03 | 0.101 | 1.83 | (1.02, 3.28) | 0.04 | |
| 3. | 1846T | 0 | 0.520 | 0.520 | 0.540 | ||||||
| 1846C | 1 | 0.480 | 0.480 | 1.00 | (0.72, 1.38) | 0.98 | 0.460 | 1.09 | (0.71, 1.68) | 0.70 | |
| Haplotype 1174-1775 | |||||||||||
| CA | 00 | 0.744 | 0.835 | 1 | 0.861 | 1 | |||||
| CG | 01 | 0.173 | 0.115 | 1.68 | (1.10, 2.59) | 0.02 | 0.094 | 2.11 | (1.16, 3.85) | 0.02 | |
| TA | 10 | 0.083 | 0.049 | 1.90 | (1.07, 3.35) | 0.03 | 0.038 | 2.53 | (0.86, 7.49) | 0.09 | |
| TG | 11 | 0 | 0 | 0 | |||||||
0 represents the common allele at each locus; 1 is the uncommon allele. Haplotype alleles for SNP1 (1174) and SNP2 (1775) are listed in order. Odds ratio (OR) and 95% confidence intervals represent a comparison of the cases with the two respective control groups with an unadjusted analysis.