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. 2003 Nov 17;198(10):1573–1582. doi: 10.1084/jem.20030298

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Effect of IP administration of TAT-Δp85 on airway inflammation after OVA sensitization and challenge. Analysis of inflammatory cells from BAL fluid 24 h after last OVA challenge. Positive (▪) and negative (□) controls are OVA and saline challenged animals, respectively. These animals received no other treatment. OVA challenge caused increased total cell count, which is largely composed of eosinophils. Increase in lymphocytes and neutrophils are recorded on a different scale (see ordinate). There was no effect on macrophage number. Migration of eosinophils and lymphocytes is blocked progressively with 3–10 mg/kg TAT-Δp85 but unaffected by 10 mg/kg Δp85 lacking the TAT domain. TAT-Δp85 has no effect on the migration of neutrophils, which is minimal. Each bar represents the mean ± SEM of 4–6 mice. *P < 0.05 and **P < 0.01 compared with positive control group. ND, not detectable.