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. 2003 Nov 17;198(10):1573–1582. doi: 10.1084/jem.20030298

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Effects of TAT-Δp85 on eosinophil accumulation in BAL fluid 12 h after intranasal administration of IL-5. Cell counts were obtained from animals receiving IL-5 + either control Δp85 (lacking TAT domain) or TAT-Δp85. Eosinophils were not detectable in airways of animals before challenge with IL-5. TAT-Δp85 blocked progressively the eosinophil migration caused by IL-5. Δp85 lacking the TAT domain was not different from IL-5 alone. Accordingly, TAT-Δp85 blocks both IL-5 synthesis (Fig. 6) as well as the chemotactic effects of IL-5 on eosinophils. Each bar represents the mean ± SEM of 4–6 mice. *P < 0.05 and **P < 0.01 compared with positive control group. ND, not detectable.