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Effect of CMPD 167 infusion into macaques infected with SIVmac251, SIVB670, or SHIV-89.6P. Twice-daily CMPD 167 therapy was commenced on day 0 (indicated by vertical line). After 14 d, therapy was administered once daily (arrowhead, 1X) for an additional 14 d, until day 28, when treatment was stopped (arrowhead, END). The dotted line indicates the viral load “baseline” at the time therapy was initiated. Each panel represents the study of an individual macaque.
