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. 2003 Dec 1;198(11):1689–1698. doi: 10.1084/jem.20031162

Figure 4.

Figure 4.

Lesion development and parasite burden after inoculation of lack-targeted L. major. Wild-type BALB/c mice (A and D), TCR Cα−/− BALB/c mice (B), or RAG-2–deficient BALB/c mice (C) were infected in the hind footpad with 2 × 106 lack-targeted L. major using the indicated strains (four to five mice per data point). Lesion development in the left footpad was monitored using calipers. Parasites recovered from the draining popliteal lymph nodes of wild-type BALB/c mice infected for 125 d (E) or RAG-2–deficient BALB/c mice infected for 80 d (F) with the indicated lack-targeted parasites. Bars indicate averaged parasite dilution factors (three to five mice per group). Dilution factors for individual mice are also shown: ♦, L. major lack++/−−; ▴, L. major lack+−/−−; ▪, L. major lack++Δ/−. Similar data (not depicted) were obtained for L. major lack−+/−−.