Table I.
Patient | HIV RNAa | CD4 countb | HLA-DRB1 | HAARTc | Treatmentd |
---|---|---|---|---|---|
Group 1 | |||||
12C | <50 | 677 | *0901, *11 | 48 | DdI, D4T EFV |
12B | <50 | 667 | *0101, *07 | 60 | D4T, 3TC, RIT |
11C | <50 | 1,037 | *0101, *08 | 48 | EFV (DMP 266-06), IND |
13C | <50 | 461 | *0401, *11 | 48 | D4T, 3TC, IND |
10C | <50 | 789 | *11, *15 | 12 | RIT, IND, Comb (AZT/3TC) |
09B | <50 | 400 | *0401, *1501 | 13 | D4T, 3TC, NFV |
02B | <50 | 604 | ND | 14 | 3TC, VER, NFV, D4T |
03C | <50 | 1,064 | *0401, *07 | 12 | 3TC, AZT, ABC |
11B | <50 | 574 | *13, *15 | 12 | Comb (AZT/3TC), NFV |
07B | <50 | 443 | *07, *15 | 12 | D4T, 3TC, RIT |
Group 2 | |||||
111 | 45,000 | 420 | *13, *13 | 72 | AZT, 3TC |
112 | 30,000 | 529 | *03, *04 | 60 | AZT, 3TC |
113 | 65,000 | 606 | *11, *15 | 24 | D4T, 3TC, IND |
114 | 40,000 | 406 | *0103, *07 | 60 | D4T, 3TC, IND |
115 | 10,000 | 771 | *07, *11 | 60 | 3TC, AZT, EFV |
116 | 33,452 | 420 | *14, *14 | 48 | 3TC, AZT, EFV |
117 | 65,007 | 344 | *04, *13 | 48 | ND |
118 | 73,902 | 386 | ND | 72 | 3TC, AZT, ABC |
Group 1, patients with therapy success and no viral rebounds; Group 2, patients with therapy failure due to several viral rebounds throughout therapy.
Copies of HIV-1 RNA/ml of plasma at the time of study.
Peripheral CD4+ T lymphocyte count at the time of study.
Duration of current regimen (months).
Antiretroviral drug abbreviations: ABC, abacavir; AZT, zidovudine; D4T, savudine; EFV, efavirenz; IND, indinavir; NFV, nelfinavir; 3TC, lamivudine.