Table II.

Proliferation and Cytokine Production by HIV Peptide–specific CD4⁺ T Cells in Aviremic Patients

Patient	Peptide	Sequence	PercentCFSElow CD4+	DBLFa	CD69+ IL-2+	CD69+ IFN-γ1	IL-2+/IFN-γ1	IL-2+	IFN-γ1
12C	G067	WIILGLNKIVRMYSP	20	0.11	0.1	0.05	0.05	0.05	<0.01
	G065	PVGEIYKRWIILGLN	15	0.08	0.07	0.03	0.03	0.04	<0.01
12B	G076	YKTLRAEQASQEVKN	8	0.05	0.05	0.02	0.02	0.03	0.03
	G067	VDLSHFLKEKGGLEG	6	0.05	0.05	0.02	0.02	0.03	<0.01
11C	G065	IYKRWIILGLNKIVR	8	0.07	0.07	0.03	0.03	0.04	<0.01
	G067	WIILGLNKIVRMYSP	7.5	0.04	0.05	0.02	0.02	0.03	<0.01
13C	G067	DRVHPVHAGPIAPGQ	7	0.03	0.05	0.02	0.02	0.03	<0.01
	N010	LEKHGAITSSNTAAT	6.5	0.03	0.04	0.02	0.02	0.02	<0.01
10C	N012	SSNTAATNAACAWLE	7.5	0.05	0.04	0.02	0.02	0.02	<0.01
	G072	IRQGPKEPFRDYVDR	6	0.03	0.04	0.02	0.02	0.02	<0.01
09B	G057	PGQMREPRGSDIAGT	10	0.05	0.06	0.03	0.03	0.03	<0.01
	G040	KVVEEKAFSPEVIPM	7	0.03	0.05	0.02	0.02	0.03	<0.01
02B	N010	LEKHGAITSSNTAAT	9	0.05	0.06	0.03	0.03	0.03	<0.01
	G055	PVHGPIAPGQMREP	7.5	0.04	0.04	0.02	0.02	0.02	<0.01
03C	N048	LAFHHVARELHPEYF	11	0.06	0.07	0.04	0.04	0.03	<0.01
	G040	KVVEEKAFSPEVIPM	6.3	0.04	0.04	0.02	0.02	0.02	<0.01
11B	G065	IYKRWIILGLNKIVR	15	0.08	0.08	0.04	0.04	0.04	<0.01
	N012	SSNTAATNAACAWLE	8	0.04	0.05	0.02	0.02	0.03	<0.01
07B	N017	EVGFPVIPQVPLRPM	12	0.06	0.07	0.04	0.04	0.03	<0.01
	G057	PGQMREPRGSDIAGT	6.7	0.03	0.04	0.02	0.02	0.02	<0.01
		Median	9.2	0.051	0.056	0.026	0.026	0.029	NA

Values of percent CFSE^low CD4⁺ are the medians of five independent experiments. The percentages of cytokine production were measured after 12 h after stimulations of patients' PBMCs with HIV-specific peptides. The data depicted are the medians of three separate experiments. Values <0.01 indicate undetectable frequencies. NA, not applicable.

^aDBLF, deduced baseline frequency derived from the 6-d CFSE-based proliferation assay.