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. 2003 Aug 18;198(4):645–651. doi: 10.1084/jem.20022220

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Impaired resorptive function of TREM-2–deficient immature OCs. Resorptive function of normal and TREM-2–deficient OCs on dentin slices (a–f). Monocytic precursors from healthy individuals (a and b) and TREM-2–deficient patients (c–f) were cultured on dentin slices. At day 10, dentin slices were stained with hematoxylin and inspected by light microscopy before (a, c, and e) and after (b, d, and f) cell removal. Resorption pits appear as dark spots stained with hematoxylin after cell removal. Normal monocytes differentiated into multinucleated OCs (a) that generated resorption pits (b). In general, TREM-2–deficient mononuclear immature OCs (c) did not excavate resorptive pits (d). Only a few pits were detected (f) that corresponded in number to the few multinucleated cells generated (e).