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. 2003 Aug 18;198(4):591–602. doi: 10.1084/jem.20022042

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Copyright © 2003, The Rockefeller University Press

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Figure 3. — mIgM(P436S) mice show diminished responses to immunization with different Ag carrier and haptenation ratios. Both mouse strains were immunized with NP₂₂-CGG (A), NP₃-CGG (B), and NP₁₅-HSA (C) and the percentage of λ⁺/NIP⁺ splenocytes determined by FACS^® analysis on day 12. Error bars indicate SEM of 3–4 mice per group in each of 2–3 separate experiments (i.e., at least 6 mice per group total). Mutant mice (solid bars) showed lower Ag-specific B cell expansion than mIgM mice (open bars) after all immunizations (P < 0.005 for NP₂₂-CGG, NP₃-CGG, and 50 μg of NP₁₅-HSA) but responded to all of them except for 5 μg of NP₃-CGG, in which case the response is not substantially different from the alum control.