Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2003 Aug 18;198(4):591–602. doi: 10.1084/jem.20022042

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2003, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Specific antiserum rescues the primary response in mIgM(P436S) mice. Serum was obtained from cardiac puncture of JhD and BALB/c (naive and 2 wk after immunization with CGG) mice. Tail vein injection of 200 μl serum into mIgM(P436S) mice was followed by i.p. immunization with 5 μg of NP₂₂-CGG three hours later. At day 12 the percentage of λ⁺/NIP⁺ (A) and λ⁺/PNA⁺ (B) splenocytes were determined by FACS^® analysis. Administration of immune BALB/c serum (black) led to reconstitution of the primary immune response in comparison to mIgM(P436S) mice that received no serum (white, P < 0.005), JhD serum (horizontal stripes, P < 0.005), naive BALB/c serum (diagonal stripes, P < 0.005), or immune BALB/c serum (black, P < 0.005). The influence of NP specific IgM on the response of mIgM(P436S) mice (gray) was compared with the response in mIgM (black) and mIgM(P436S) (white) mice at 5 μg and 50 μg NP22-CGG (C) (P < 0.01 for 5 μg and P < 0.05 for 50 μg between mIgM or mIgM(P436S)+Ab and mIgM(P436S)).