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. 2003 Aug 18;198(4):615–621. doi: 10.1084/jem.20030448

Figure 4.

Figure 4.

CCR7−/− DCs fail to migrate to the draining lymph node but efficiently condition the tissue for increased migration of CCR7+/+ DCs. Mice (two per condition) were injected with 106 CCR7+/+ or CCR7−/− syngeneic DCs, TNF, or PBS. 24 h later, all mice received a second injection at the same site of 106 CMTMR-labeled CCR7−/− or CCR7+/+ DCs. The total number of migrated CMTMR-labeled DCs was measured in the draining lymph node after an additional 24 h (gate). Live cells gated as propidium iodide (PI) negative are shown. One of two experiments performed is shown.