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. 2003 Sep 1;198(5):679–691. doi: 10.1084/jem.20030066

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Copyright © 2003, The Rockefeller University Press

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Figure 7. — The structural interactions around residue 156 constrain the antigen-binding cleft of HLA-B*4402 (156 Asp) relative to HLA-B*4403 (156 Leu) and alter the orientation of peptide side chains. The side chain of residue 156 is shown in yellow and forms a unique H-bond with Asp 114 in B*4402 (A) that is missing in B*4403 (B), where instead Asp 114 is reoriented to maximize its H-bond network with Arg 97, creating a wider cavity in this region of the cleft. Peptide, green; HLA heavy chain, gray; H-bonds, dotted lines; W, water.